Physical Activity Before and During Pregnancy and Risk of Gestational Diabetes Mellitus
Open Access
- 27 September 2010
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 34 (1), 223-229
- https://doi.org/10.2337/dc10-1368
Abstract
OBJECTIVE: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is associated with a substantially elevated risk of adverse health outcomes for both mothers and offspring. Physical activity may contribute to the prevention of GDM and thus is crucial for dissecting the vicious circle involving GDM, childhood obesity, and adulthood obesity, and diabetes. Therefore, we aimed to systematically review and synthesize the current evidence on the relation between physical activity and the development of GDM. RESEARCH DESIGN AND METHODS: Medline, EMBASE, and Cochrane Reviews were searched from inception to 31 March 2010. Studies assessing the relationship between physical activity and subsequent development of GDM were included. Characteristics including study design, country, GDM diagnostic criteria, ascertainment of physical activity, timing of exposure (prepregnancy or early pregnancy), adjusted relative risks, CIs, and statistical methods were extracted independently by two reviewers. RESULTS: Our search identified seven prepregnancy and five early pregnancy studies, including five prospective cohorts, two retrospective case-control studies, and two cross-sectional study designs. Prepregnancy physical activity was assessed in 34,929 total participants, which included 2,813 cases of GDM, giving a pooled odds ratio (OR) of 0.45 (95% CI 0.28–0.75) when the highest versus lowest categories were compared. Exercise in early pregnancy was assessed in 4,401 total participants, which included 361 cases of GDM, and was also significantly protective (0.76 [95% CI 0.70–0.83]). CONCLUSIONS: Higher levels of physical activity before pregnancy or in early pregnancy are associated with a significantly lower risk of developing GDM.Keywords
This publication has 40 references indexed in Scilit:
- Effects of treatment in women with gestational diabetes mellitus: systematic review and meta-analysisBMJ, 2010
- Diabetes Trends Among Delivery Hospitalizations in the U.S., 1994–2004Diabetes Care, 2010
- Maternal physical activity before and during early pregnancy as a risk factor for gestational diabetes mellitusActa Diabetologica, 2009
- Exercise, Vascular Wall and Cardiovascular DiseasesSports Medicine, 2009
- Management of diabetes from preconception to the postnatal period: summary of NICE guidanceBMJ, 2008
- Associations of Physical Activity and Inactivity Before and During Pregnancy With Glucose ToleranceObstetrics & Gynecology, 2006
- An Increase in the Incidence of Gestational Diabetes Mellitus: Northern California, 1991–2000Obstetrics & Gynecology, 2004
- Correlates of recreational physical activity in early pregnancyThe Journal of Maternal-Fetal & Neonatal Medicine, 2003
- Quantifying heterogeneity in a meta‐analysisStatistics in Medicine, 2002
- Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by13C Nuclear Magnetic Resonance SpectroscopyNew England Journal of Medicine, 1990