Selectivity: A Key to Synthetic Efficiency
- 21 January 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4582), 245-250
- https://doi.org/10.1126/science.219.4582.245
Abstract
The efficient synthesis of organic compounds requires the development of processes with enhanced selectivity. Selectivity is categorized according to chemical reactivity (chemoselectivity), orientation (regioselectivity), and spatial arrangement (diastereoselectivity and enantioselectivity). Recent developments in reduction-oxidation methods and C—C bond forming reactions illustrate some solutions to problems of selectivity. The design of selectivity-inducing groups and the increased role of main group and transition metals in enhancing selectivity are especially noted.Keywords
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