Experts in the field of tuberculosis have expressed concern that in some cases prolonged use of cortisone or corticotrophin (ACTH) may cause a lowering of a patient's resistance against tuberculosis. As a result the National Tuberculosis Association recently published the following recommendation:1 Because the action of ACTH and cortisone upon factors of resistance to tuberculosis has been shown to be deleterious in at least three species of experimental animals (mice, guinea pigs, and rabbits), and there is strongly suggestive evidence along the same lines in human beings, it is recommended that these substances not be used in patients with active tuberculosis, and that they be used with extreme caution even in human beings with possibly latent tuberculosis infection, until such time as further investigative work has shown that such administration may be safe. The routine diagnostic examination for tuberculosis of patients under physicians' care is especially necessary for patients