Enantio-complementary total asymmetric syntheses of prostaglandin E2 and prostaglandin F2?
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 4,p. 1317-1320
- https://doi.org/10.1039/p19810001317
Abstract
The racemic ketone (6) was converted into the diastereoisomeric alcohols (7) and (8) using actively fermenting yeast. These alcohols were separated and converted into the bromohydrins (–)-(9) and (+)-(9). The bromohydrin (–)-(9) was converted into prostaglandin E2(1) and prostaglandin F2α(2) by reaction of the chiral cuprate reagent (15) with the tricyclic ketone (10), while the bromohydrin (+)-(9) was converted into the prostaglandins by reaction of the epoxyacetal (11) with the same cuprate reagent (15).This publication has 5 references indexed in Scilit:
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