PROGNOSTICALLY SIGNIFICANT CLASSIFICATION OF IMMUNE CHANGES IN AIDS WITH KAPOSIS-SARCOMA

Abstract

Sixteen immunological parameters were assessed quantitatively for their value in providing an immunlogically-based on prognostically significant classification of the immune alteration in 97 patients with AIDS and Kaposi''s sarcoma (AIDS-KS). The dimensions of reductions in the T4 (T helper-inducer cells) subpopulation of lymphoid cells in the T4-T8 ratio were found to correlate most closely with prognosis. Most other immunological changes did not relate to clinical course. T4 lymphocyte levels > 300/.mu.L and a T4-T8 ratio > 0.5 indicated a relatively good prognosis, eg, 85% to 95% survival at 12 months. T4 levels < 100/.mu.L and/or a T4-T8 ratio < 0.2 had a very poor prognosis, eg, < 25% survival at 12 months. T4 levels < 100/.mu.L and/or a T4-T8 ratio < 0.2 had a very poor prognosis, eg. < 25% survival at 12 months. Intermediate T4 levels and T4-T8 ratios had intermediate prognosis. These immunological findings were found to have independent prognostic value for survival when compared with disease classifications based on tumor stage (I through IV) or on clinical status A (without) or B (with fever, night sweats, or weight loss). Reduced proliferative capacity, increased OKT10 antigen expression, elevated levels of serum IgA, and immune complexes also correlated with prognosis. Elevated levels of serum IgG, cellular HLA-DR expression, and skin test anergy occurred frequently in AIDS-KS but did not have prognostic significance. Variations in level of total lymphocyte, T8 (T suppressor/ cytotoxic) cell, gamma FcR receptor-positive cell number, NK activity, or level of serum IgM were less common in AIDS-KS and did not correlate with prognosis.