Pharmacologic Properties of a New Tranquillizing Agent, 2-Methyl-2-propyltrimethylene butylcarbamate carbamate (Tybamate)

Abstract

Tybamate (2-methyl-2-propyltrimethylene butylcarbamate carbamate) shares many pharmacological properties with meprobamate. Their common properties include the ability to tame wild and aggressive cats, the ability to shorten limbic seizures in doses that do not affect spontaneous cortical potentials, the selective depressant effect on interneurons, and a centrally mediated muscle relaxant action. Tybamate differs from meprobamate in that it reverses the electroencephalographic effect of the hallucinogen lysergic acid diethylamide (LSD-25) in rabbits, antagonizes the serotonin-produced blood pressure rise in dogs, and is extensively bound to plasma protein. The drug is well tolerated over long periods of time by rats, dogs and monkeys, and tolerance to its effects does not readily develop.