Leukaemia stem cells and the evolution of cancer-stem-cell research
Top Cited Papers
- 1 April 2005
- journal article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (4), 311-321
- https://doi.org/10.1038/nrc1592
Abstract
Many cancers seem to depend on a small population of 'cancer stem cells' for their continued growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be described. The origins of these cells are controversial, and their biology - like that of their normal-tissue counterpart, the haematopoietic stem cell (HSC) - is still not fully elucidated. However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a thorough understanding of its biology - particularly of how the LSC differs from the HSC - might allow it to be selectively targeted, improving therapeutic outcome.Keywords
This publication has 119 references indexed in Scilit:
- Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic LeukemiaScience, 2004
- Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem CellsScience, 2004
- Multiple niches for Notch in cancer: context is everythingCurrent Opinion in Genetics & Development, 2003
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences, 2003
- Two Distinct Notch1 Mutant Alleles Are Involved in the Induction of T-Cell Leukemia in c-myc Transgenic MiceMolecular and Cellular Biology, 2000
- The Hallmarks of CancerCell, 2000
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsCell, 1991
- Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny. The 10th Walter Hubert LectureBritish Journal of Cancer, 1978
- Primary Bioassay of Human Tumor Stem CellsScience, 1977