Amino Acid Sequence of the Basic Protein of the Myelin Membrane
- 1 November 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 67 (3), 1425-1431
- https://doi.org/10.1073/pnas.67.3.1425
Abstract
The amino acid sequences of the encephalitogenic basic protein, A1, from bovine and human myelin are similar, differing by only 11 residues. The sequence reveals that while basic residues are spread randomly over most of the polypeptide chain, several regions (8-10 residues) exist that are nonpolar in character. The bovine protein has 170 residues with molecular weight 18,400. The human protein, which has an additional His-Gly sequence, contains 172 residues. The major encephalitogenic determinant (tryptophan region) of the bovine protein differs from the human only by a lysine to arginine substitution. The structural features of the A1 protein are discussed, with special reference to its role in stabilization of the myelin membrane, and its relation to multiple sclerosis.Keywords
This publication has 25 references indexed in Scilit:
- Experimental Allergic Encephalomyelitis: Synthesis of Disease-Inducing Site of the Basic ProteinScience, 1970
- Allergic encephalomyelitis: Preparation of the encephalitogenic basic protein from bovine brainArchives of Biochemistry and Biophysics, 1970
- Estimation of the molecular weight of flexible disordered proteins by exclusion chromatographyJournal of Chromatography A, 1969
- Digestion of an Arg–Pro Bond by Trypsin in the Encephalitogenic Basic Protein of Human MyelinNature, 1969
- Encephalitogenic Protein: StructureScience, 1969
- Allergic encephalomyelitis: Cleavage of the C-tryptophyl bond in the encephalitogenic basic protein from bovine myelinArchives of Biochemistry and Biophysics, 1969
- The structure of the terminal regions of the encephalitogenic basic protein from bovine myelinArchives of Biochemistry and Biophysics, 1969
- CHEMICAL STUDIES ON EXPERIMENTAL ALLERGIC ENCEPHALOMYELITISJournal of Neurochemistry, 1966
- Human fibrinopeptides isolation, characterization and structureBiochimica et Biophysica Acta (BBA) - General Subjects, 1966
- THE ISOLATION FROM BOVINE SPINAL CORD OF A HOMOGENEOUS PROTEIN WITH ENCEPHALITOGENIC ACTIVITY*Journal of Neurochemistry, 1962