The structure of human collapsin response mediator protein 2, a regulator of axonal growth
- 5 December 2006
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 101 (4), 906-917
- https://doi.org/10.1111/j.1471-4159.2006.04401.x
Abstract
Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers.Keywords
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