DISSEMINATED HISTIOCYTOSIS AND INTESTINAL MALAKOPLAKIA - OCCURRENCE DUE TO MYCOBACTERIUM-INTRACELLULARE INFECTION

Abstract

Disseminated histocytic proliferation and intestinal malakoplakia due to M. intracellulare occurred in a 2 yr old white boy. EM and light microscopic examination of autopsy material disclosed disseminated histiocytosis and malakoplakia of the intestine with numerous intracellular acid-fast bacilli. The isolated organism produced a similar disseminated histiocytosis and finally death when injected into experimental animals. A review of the literature showed only 12 previously reported cases of disseminated histiocytosis due to M. intracellular infection.. A previous report of malakoplakia due to non-tuberculous mycobacterial infection was not found.