Aminoacyl-RNA Synthesis Catalyzed by an RNA
- 3 February 1995
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 267 (5198), 643-647
- https://doi.org/10.1126/science.7530860
Abstract
An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (> or = 10(5) times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.Keywords
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