Several preliminary reports have appeared in the literature indicating that shigellosis responds favorably to treatment with streptomycin. The National Research Council Committee1reported 2 cases of Shigella-caused dysentery in which a daily dosage of 1.5 Gm. of streptomycin was given intramuscularly for five days. In both cases, the stool cultures promptly became negative and an uneventful recovery ensued. Pulaski and Amspacher2treated 10 patients who had bacillary dysentery due to Shigella with streptomycin in doses of 1 to 4 Gm. daily for periods ranging from one to twelve days. The drug was administered orally in 2 cases, parenterally in 6 and in combination in 2. These investigators reported good to excellent results in nearly every case, with no instances of relapse during a one to four month follow-up period. In view of the toxic reactions observed in connection with parenterally administered streptomycin, it was considered worth while in