Multiple‐dose Cimetidine Administration Does Not Influence the Single‐dose Pharmacokinetics of Quinapril and Its Active Metabolite (CI‐928)

Abstract

The potential effect of cimetidine on the pharmacokinetic profiles of quinapril and its active metabolite CI‐928 was evaluated in eight healthy volunteers. Each subject received a single 40‐mg quinapril dose on days 1 and 12 and cimetidine 300 mg four times daily on days 8 through 13. Serial blood and urine samples were collected for assay of quinapril and CI‐928 concentrations. No statistically significant differences were observed in quinapril or CI‐928 C_max, t_max, AUC_(0‐∞),β, or percent of dose excreted in urine values for quinapril administered alone and in combination with cimetidine. Therefore, multiple‐dose cimetidine administration does not influence the single‐dose pharmacokinetics of quinapril and its active metabolite, CI‐928, in healthy volunteers.