Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo
Top Cited Papers
- 15 July 2012
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 18 (8), 1297-1302
- https://doi.org/10.1038/nm.2823
Abstract
Joon-Mo Yang and colleagues have developed a new endoscopic technique for the in vivo imaging of internal organs, combining endoscopic ultrasound and photoacoustic endoscopy in a single instrument. In addition to improved resolution, imaging depth, multimodal contrast, and distal-end scanning, the new hybrid imaging modality can also provide functional information such as hemoglobin concentration and blood oxygenation. Feasibility is shown in vivo by simultaneous photoacoustic endoscopy and endoscopic ultrasound imaging of the upper and lower gastrointestinal tracts of rats and rabbits. At present, clinicians routinely apply ultrasound endoscopy in a variety of interventional procedures that provide treatment solutions for diseased organs. Ultrasound endoscopy not only produces high-resolution images, but also is safe for clinical use and broadly applicable. However, for soft tissue imaging, its mechanical wave–based image contrast fundamentally limits its ability to provide physiologically specific functional information. By contrast, photoacoustic endoscopy possesses a unique combination of functional optical contrast and high spatial resolution at clinically relevant depths, ideal for imaging soft tissues. With these attributes, photoacoustic endoscopy can overcome the current limitations of ultrasound endoscopy. Moreover, the benefits of photoacoustic imaging do not come at the expense of existing ultrasound functions; photoacoustic endoscopy systems are inherently compatible with ultrasound imaging, thereby enabling multimodality imaging with complementary contrast. Here we present simultaneous photoacoustic and ultrasonic dual-mode endoscopy and show its ability to image internal organs in vivo, thus illustrating its potential clinical application.Keywords
This publication has 36 references indexed in Scilit:
- Detection of Dysplasia in Barrett's Esophagus With In Vivo Depth-Resolved Nuclear Morphology MeasurementsGastroenterology, 2011
- Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagusNature Medicine, 2010
- In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New DepthsChemical Reviews, 2010
- Photoacoustic tomography of water in phantoms and tissueJournal of Biomedical Optics, 2010
- Multiscale photoacoustic microscopy and computed tomographyNature Photonics, 2009
- Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agentsNature Nanotechnology, 2009
- Mediastinal staging of NSCLC with endoscopic and endobronchial ultrasoundNature Reviews Clinical Oncology, 2009
- Carbon nanotubes as photoacoustic molecular imaging agents in living miceNature Nanotechnology, 2008
- Imaging in the era of molecular oncologyNature, 2008
- Comprehensive volumetric optical microscopy in vivoNature Medicine, 2006