Effect of Rutin on Anaphylactic and Histamine Shock

Abstract

Guinea pigs were sensitized by an intraperit. injn. of 0.25 ml. of normal horse serum. After 12 days the animals were shocked by a parenteral dose of horse serum. Three animals received 2 mg. of rutin intraperit. 30-45 mins. before anaphy-lactic shock was produced. These 3 plus 5 others were given intracardially 0.05 ml. of normal horse serum per 100 gm. body wt. The 3 rutin-injd. animals developed no symptoms, whereas the 5 controls died in anaphylactic shock. Five animals received 1 mg. of rutin intraperit. 30-45 min. before shocking, and 6 animals were used as controls. All 11 animals were then given 0.5 ml. of horse serum intracardially. The rutinized animals developed no symptoms, whereas the 6 controls died. 9 animals were given 1 mg. of rutin in 0.1 ml. of propylene glycol intraperit. 30-45 min. before receiving a minimal lethal dose of histamine, while 9 controls received only propylene glycol. Although rutin protected the animals against the fatal effects of anaphylactic shock, it did not against those of histamine shock.