Biosynthesis of Iso-Fatty Acids in Myxobacteria: Iso-Even Fatty Acids Are Derived by α-Oxidation from Iso-Odd Fatty Acids
- 21 December 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (2), 532-533
- https://doi.org/10.1021/ja043570y
Abstract
The biosynthesis of iso-fatty acids was investigated in the myxobacteria Myxococcus xanthus and Stigmatella aurantiaca by feeding labeled precursors of these fatty acids and by conducting detailed analysis of the fatty acid profiles and fatty acid MS and NMR spectra. These experiments revealed that in S. aurantiaca all iso-even fatty acids are formed via α-oxidation of iso-odd fatty acids and not by using valine-derived isobutyryl-CoA.Keywords
This publication has 7 references indexed in Scilit:
- Biosynthesis of Volatiles by the MyxobacteriumMyxococcus xanthusChemBioChem, 2004
- A Novel Biosynthetic Pathway Providing Precursors for Fatty Acid Biosynthesis and Secondary Metabolite Formation in MyxobacteriaPublished by Elsevier ,2002
- Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectinNature Biotechnology, 2000
- α-Oxidation of Fatty Acids in Higher PlantsPublished by Elsevier ,1999
- Molecular Cloning and Expression of Fatty Acid α-Hydroxylase from Sphingomonas paucimobilisJournal of Biological Chemistry, 1997
- Novel avermectins produced by mutational biosynthesis.The Journal of Antibiotics, 1991
- Isovaleric acid as a precursor of odd numbered iso fatty acids in TetrahymenaLipids, 1974