Changes of Uric Acid Level in Rat Brain After Focal Ischemia
- 1 March 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 46 (3), 851-853
- https://doi.org/10.1111/j.1471-4159.1986.tb13049.x
Abstract
Changes of uric acid level in rat cerebral hemisphere after left middle cerebral artery (MCA) occlusion were studied by reversed-phase HPLC with electrochemical detection. Uric acid level in the normal group was 2.98 nmol/g tissue. Uric acid concentration of the left hemisphere in the left MCA-occluded group progressively increased after occlusion, and reached a maximum value of 67.26 nmol/g tissue 24 h after ischemia. Uric acid levels in the right hemisphere remained unchanged. Uric acid concentration of the left hemisphere in sham-operated group was 9.29 nmol/g tissue 24 h after the operation.Keywords
This publication has 13 references indexed in Scilit:
- Electrochemical Detection of Ascorbic and Uric Acids in the Eluate from Reversed-Phase High-Performance Liquid Chromatography with Newly Developed Rigid-Type Porous Polymer Packing (Polymetacrylate Gels)Journal of Liquid Chromatography, 1985
- Identification of Hypoxanthine Transport and Xanthine Oxidase Activity in Brain CapillariesJournal of Neurochemistry, 1985
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985
- Postmortem changes of uric acid in various rat tissues: Determination of uric acid by reversed-phase high-performance liquid chromatography with electrochemical detectionAnalytical Biochemistry, 1984
- Inhibition of free radical‐induced DNA damage by uric acidFEBS Letters, 1984
- A simple, rapid and sensitive method for the determination of rat serum uric acid by reversed-phase high-performance liquid chromatography with electrochemical detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1983
- Oxypurines in cerebrospinal fluid as indices of disturbed brain metabolism. A clinical study of ischemic brain diseases.Stroke, 1983
- Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proceedings of the National Academy of Sciences, 1981
- Metabolic basis for disorders of purine nucleotide degradationMetabolism, 1981
- Peroxidative Changes in Brain Cortical Fatty Acids and Phospholipids, as Characterized During Fe2+‐ and Ascorbic Acid‐Stimulated Lipid Peroxidation In VitroJournal of Neurochemistry, 1980