The role of cyclic AMP in parathyroid hormone action in the toad bladder
- 1 December 1978
- journal article
- research article
- Published by Springer Nature in The Journal of Membrane Biology
- Vol. 41 (4), 329-335
- https://doi.org/10.1007/bf01871997
Abstract
Summary Parathyroid hormone (PTH) inhibited active transport of inorganic phosphate and stimulated an increase in cyclic AMP concentration in the urinary bladder of the toad,Bufo marinus. Active transport of phosphate in the toad bladder was also inhibited by an analog of cyclic AMP (dibutyryl cyclic AMP) and by other drugs (pitressin and theophylline) which increase toad bladder intracellular cyclic AMP concentration. These data support the concept that cyclic AMP may be the mediator of PTH-induced phosphate transport inhibition in the toad bladder.Keywords
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