Studies of Inhibitory Effect of Ammonium Ions in Several Virus-Tissue Culture Systems

Abstract

The antiviral effect of ammonium ions, previously shown in dog kidney cells against influenza virus, has been reexamined with 10 viruses in 10 tissue culture cell lines. Only influenza virus appeared to be affected by the inhibitor, which functioned in a number of cell systems. The effect was shown to be independent of virus inoculum size and therefore apparently on the host cell. The inhibition was demonstrated in suspended allantoic membrane cultures, and a marginal effect was also observed in intact chick embryos.