Metabolism of Papaverine I. Identification of Metabolites in Rat Bile
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (7), 413-420
- https://doi.org/10.3109/00498257509056111
Abstract
1. After hydrolysis with glusulase of bile from rats treated with papaverine, four metabolites (A, B, C and D) were separated. 2. The structures of A, B and C were established as the monodemethylated compounds, 4′-desmethyl-, 7-desmethyl-, and 6-desmethylpapaverine, respectively. 3. D was formed from papaverine by bis-demethylation. Since it was found in cat bile after administering either A or C, but not B, it was identified as 4′,6-desmethylpapaverine.Keywords
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