Connective Tissue Growth Factor in Retrocorneal Membranes and Corneal Scars
- 10 August 2000
- journal article
- research article
- Published by S. Karger AG in Ophthalmologica
- Vol. 214 (5), 341-346
- https://doi.org/10.1159/000027517
Abstract
We studied the localization and distribution of connective tissue growth factor (CTGF) in corneal scar tissue and membranes using in situ hybridization in 8 corneas from keratoplasty and 4 normal corneas. Identification of the cells was done with immunohistochemistry for SM-α-actin, vimentin, and Lu5. CTGF mRNA was found in activated corneal fibroblasts in 7 of 8 scars, 7 of 8 retrocorneal membranes and 2 subepithelial membranes, whereas the control corneas showed no CTGF mRNA expression. Vimentin was positive in all scars, retrocorneal and subepithelial membranes, SM-α-actin in 7 of 8 scars and 6 of 8 retrocorneal membranes. These results suggest that CTGF plays a crucial role in corneal wound healing and membrane formation.Keywords
This publication has 4 references indexed in Scilit:
- TGF‐β1 stimulates cultured human fibroblasts to proliferate and produce tissue‐like fibroplasia: A fibronectin matrix‐dependent eventJournal of Cellular Physiology, 1997
- Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic SclerosisJournal of Investigative Dermatology, 1995
- Fibroblast growth factorMolecular and Cellular Endocrinology, 1986
- Levels of epidermal growth factor in mice tissues measured by a specific radioreceptor assayLife Sciences, 1976