Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons
- 24 June 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 264 (5167), 1921-1924
- https://doi.org/10.1126/science.8009222
Abstract
The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-alpha and especially by IFN-gamma was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice). The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.Keywords
This publication has 40 references indexed in Scilit:
- Requirement for Transcription Factor IRF-1 in NO Synthase Induction in MacrophagesScience, 1994
- Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte developmentCell, 1993
- The interferon‐stimulable response elements of two human genes detect overlapping sets of transcription factorsEuropean Journal of Biochemistry, 1993
- Inhibition of Rev-Mediated HIV-1 Expression by an RNA Binding Protein Encoded by the Interferon-Inducible 9-27 GeneScience, 1993
- The Antiviral Effects of the Interferons and Their InhibitionJournal of Interferon Research, 1992
- Interferon-Dependent Signaling Pathways: DNA Elements, Transcription Factors, Mutations, and Effects of Viral ProteinsJournal of Interferon Research, 1992
- Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elementsCell, 1988
- Constitutive expression of (2′–5′) oligo A synthetase confers resistance to picornavirus infectionNature, 1987
- INTERFERONS AND THEIR ACTIONSAnnual Review of Biochemistry, 1987
- FACTORS MODIFYING HOST RESISTANCE TO VIRAL INFECTIONThe Journal of Experimental Medicine, 1968