Aigialomycins A−E, New Resorcylic Macrolides from the Marine Mangrove Fungus Aigialus parvus
- 7 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 67 (5), 1561-1566
- https://doi.org/10.1021/jo010930g
Abstract
Aigialomycins A−E (2−6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.Keywords
This publication has 11 references indexed in Scilit:
- Structures of Cordypyridones A−D, Antimalarial N-Hydroxy- and N-Methoxy-2-pyridones from the Insect Pathogenic Fungus Cordyceps nipponicaThe Journal of Organic Chemistry, 2001
- Marine natural products (1999)Natural Product Reports, 2001
- Bioxanthracenes from the Insect Pathogenic Fungus Cordyceps pseudomilitaris BCC 1620. II. Structure Elucidation.The Journal of Antibiotics, 2001
- Cordyanhydrides A and B. Two unique anhydrides from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620Tetrahedron Letters, 2000
- Synthetic and naturally occurring antimalarialsJournal of Heterocyclic Chemistry, 1999
- Antimalarial Activity of Macrocyclic Trichothecenes Isolated from the Fungus Myrothecium verrucariaJournal of Natural Products, 1998
- Zearalenone derivatives produced by the fungus Drechslera portulacaePhytochemistry, 1992
- New Colorimetric Cytotoxicity Assay for Anticancer-Drug ScreeningJNCI Journal of the National Cancer Institute, 1990
- Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution techniqueAntimicrobial Agents and Chemotherapy, 1979
- New zearalenone related macrolides and isocoumarins from an unidentified fungusThe Journal of Organic Chemistry, 1978