Aureomycin and Terramycin in Human Saliva.

Abstract

Levels of aureomycin or terramycin in human saliva were assayed on 32 subjects 2.5 hrs. after ingestion of capsules of 0.25 g. every 4 hrs. The means for antibiotic levels were 13 [mu]g./ml. after 0.5 g. medication, 0.4 [mu]g./ml. after 3 g., and 0.11 [mu]g./ml. 24 hrs. after the 3 g. dose. Plasma concns. were 4-10 times as great. Inhibition of salivary microorganisms (viable counts) was observed at all times, and was highest after the 3 g. dosage (90%). Mean saliva concns. following local admn. of one aureomycin or terramycin 15 mg. troche fell from 260 ug./ ml. at 1 min. to 4 fig.[mu]ml. at 3 hrs. and 0 at 24 hrs. Bacterial inhibition was greatest at 1 hr. (mean, 87%). A 2d troche added 1 hr. after the 1st increased the reduction to 97%. This inhibition was maintained for at least 1 hr.