Neighborhood socio-economic characteristics, African ancestry, and Helicobacter pylori sero-prevalence
- 21 April 2012
- journal article
- research article
- Published by Springer Nature in Cancer Causes & Control
- Vol. 23 (6), 897-906
- https://doi.org/10.1007/s10552-012-9960-7
Abstract
Purpose The authors recently reported high Helicobacter pylori sero-prevalence among African-Americans of high African ancestry. We sought to determine whether neighborhood-level socio-economic characteristics are associated with H. pylori prevalence and whether this helps explain the link between African ancestry and H. pylori. Methods Antibodies to H. pylori proteins were assessed in the serum of 336 African-American and 329 white Southern Community Cohort Study participants. Prevalence odds ratios (ORs) and 95 % confidence intervals (CIs) for CagA+ and CagA− H. pylori were calculated using polytomous logistic regression in relation to 10 Census block group-level measures of socio-economic status. Results After adjusting for individual-level characteristics, three neighborhood-level factors were significantly inversely related to CagA+ H. pylori: percent completed high school; median house values; and percent employed (comparing highest to lowest tertile, OR, 0.47, 95 % CI, 0.26–0.85; OR, 0.56, 95 % CI, 0.32–0.99; and OR, 0.59, 95 % CI, 0.34–1.03, respectively). However, accounting for these measures did not attenuate the association between African ancestry and CagA+ H. pylori, with African-Americans of low, medium, and high African ancestry maintaining two-, seven-, and ninefold increased odds, respectively, compared to whites. Conclusions Neighborhood-level measures of education, employment, and house values are associated with CagA+ H. pylori sero-prevalence, but do not explain the persistent strong relationship between African ancestry level and CagA+ H. pylori. The findings suggest that neighborhood socio-economic status can help to highlight high-risk areas for prevention and screening efforts and that the link between African ancestry and H. pylori may have a biological basis.Keywords
This publication has 37 references indexed in Scilit:
- Association between oral health and gastric precancerous lesionsCarcinogenesis: Integrative Cancer Research, 2011
- Are Associations Between Neighborhood Socioeconomic Characteristics and Body Mass Index or Waist Circumference Based on Model Extrapolations?Epidemiology, 2011
- Race, African Ancestry, and Helicobacter pylori Infection in a Low-Income United States PopulationCancer Epidemiology, Biomarkers & Prevention, 2011
- Blood Vitamin D Levels in Relation to Genetic Estimation of African AncestryCancer Epidemiology, Biomarkers & Prevention, 2010
- Helicobacter pylori Virulence Factor Genotypes in Children in the United States: Clues about Genotype and Outcome RelationshipsJournal of Clinical Microbiology, 2010
- Socioeconomic and Race/Ethnic Patterns in Persistent Infection Burden Among U.S. AdultsThe Journals of Gerontology: Series A, 2009
- Socioeconomic and psychosocial gradients in cardiovascular pathogen burden and immune response: The multi-ethnic study of atherosclerosisBrain, Behavior, and Immunity, 2008
- Cumulative life course and adult socioeconomic status and markers of inflammation in adulthoodJournal of Epidemiology and Community Health, 2008
- Tooth Loss and Helicobacter pylori Seropositivity: the Newcastle Thousand Families Cohort Study at Age 49–51 YearsHelicobacter, 2005
- Novel 180- and 480-Base-Pair Insertions in African and African-American Strains of Helicobacter pyloriJournal of Clinical Microbiology, 2004