Prevention of Autoimmunity in Experimental Lupus Erythematosus by Soluble Immune Response Suppressor
- 1 April 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4285), 56-59
- https://doi.org/10.1126/science.300174
Abstract
Young NZB/W mice, treated with injections of soluble immune response suppressor (SIRS)(supernatant from mouse spleen cells exposed to concanavalin A), showed decreased immunoglobulin levels, less antibody to cell nuclei, less proteinuria, and less renal pathology as compared with NZB/W mice receiving a control preparation. Thus, SIRS administration beginning at an early age appears to be an effective therapy of the autoimmune disease in NZB/W mice.This publication has 12 references indexed in Scilit:
- Loss of suppressor T cells in adult NZB/NZW mice.The Journal of Experimental Medicine, 1976
- Mechanisms in immune toleranceCellular Immunology, 1975
- Loss with age in NZB/W Mice of Thymic Suppressor Cells in the Graft-vs-Host ReactionThe Journal of Immunology, 1974
- Effect of Con A on Tolerance to BGG in NZB/W MiceExperimental Biology and Medicine, 1974
- Correction of T Cell Function by Thymosin in New Zealand MiceThe Journal of Immunology, 1974
- Immunofluorescence Studies on Thymocytotoxic Antibody from New Zealand Black MiceThe Journal of Immunology, 1974
- Pathogenesis of autoimmunity in New Zealand mice V. Loss of thymic suppressor functionArthritis & Rheumatism, 1974
- Increased survival of NZBW mice given multiple syngeneic young thymus graftsClinical Immunology and Immunopathology, 1973
- Enhanced Antibody Response of Mice to Polyinosinic Polycytidylic Acid by Antithymocyte Serum and its Age-Dependent Loss in NZB/W MiceThe Journal of Immunology, 1973
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951