The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinoma
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Histology
- Vol. 13 (6), 931-939
- https://doi.org/10.1007/bf01002633
Abstract
Human gastrectomy specimens, including 48 carcinomas and 25 selected benign cases showing extensive intestinal metaplasia (IM), were examined in detail histologically and histochemically. IM was classified into complete (type I), incomplete without sulphomucins (type IIA) and incomplete with sulphomucins (type IIB). Type IIB was associated with ‘intestinal’ but not ‘diffuse’ cancers (PPN-acetylsialomucins.O-acetylsialomucins were not seen in IIB IM or tumours but were observed in complete or type IIM. These findings suggest a histogenic link between incomplete IM secreting sulphomucins (or ‘colonic’ metaplasia) and ‘intestinal’ cancers of the human stomach.This publication has 34 references indexed in Scilit:
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