STUDIES ON THE CONTROL OF ANTIBODY SYNTHESIS
Open Access
- 1 July 1967
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 126 (1), 81-91
- https://doi.org/10.1084/jem.126.1.81
Abstract
In the system studied, antigenic competition between two haptenic determinants was found to be of the same extent whether the haptens were on the same or on separate carrier molecules. Suppression of antibody formation to one determinant by administration of passive antibody partially eliminated the depressive effects of antigenic competition when the two haptens were located on separate carrier molecules but had no effect on antibody production to the second hapten when the two determinants were present on the same molecule. The results are discussed in terms of the mechanisms of suppression, antigenic competition, and control of antibody formation.This publication has 14 references indexed in Scilit:
- ANTIBODY SYNTHESIS AT THE CELLULAR LEVELThe Journal of Experimental Medicine, 1966
- HOMEOSTASIS OF ANTIBODY FORMATION IN THE ADULT RATThe Journal of Experimental Medicine, 1964
- Inhibition of 19 S Antibody Synthesis by 7 S AntibodyScience, 1964
- Quantitative Studies on the Precipitation of Anti-2,4-Dinitrophenyl Antibody in Antigen ExcessThe Journal of Immunology, 1964
- Spectrometric Evaluation of the Approximate pK of the Carboxyl Group in 2,4-Dinitrophenyl-Amino AcidsBiochemistry, 1962
- ANTIBODY FORMATION IN VITROThe Journal of Experimental Medicine, 1961
- ANTIBODY FORMATIONThe Journal of Experimental Medicine, 1961
- AZOPROTEINS .2. SPECTROPHOTOMETRIC STUDY OF THE COUPLING OF DIAZOTIZED ARSANILIC ACID WITH PROTEINS1960
- A STUDY OF THE DISTRIBUTION OF 2,4-DINITROBENZENE SENSITIZERS BETWEEN ISOLATED LYMPH NODE CELLS AND EXTRACELLULAR MEDIUM IN RELATION TO INDUCTION OF CONTACT SKIN SENSITIVITYThe Journal of Experimental Medicine, 1959
- STUDIES OF HYPERSENSITIVITY TO LOW MOLECULAR WEIGHT SUBSTANCES .3. THE 2,4-DINITROPHENYL GROUP AS A DETERMINANT IN THE PRECIPITIN REACTION1954