Characteristics Common to Choleretic Increments of Bile Induced by Theophylline, Glucagon and SQ-20009 in the dog

Abstract

Theophylline, glucagon and SQ-20009 [1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic-acid ethylester hydrochloride] induce a choleresis in the dog characterized by a proportionate increase in erythritol clearance and bile flow, no increase in bile salt excretion, and by an isosmotic solution of similar electrolyte composition. The increment in bile appears to originate at the canaliculus in response to increased cyclic-AMP.