Ions As ‘Second Messengers’
- 1 June 1974
- journal article
- research article
- Published by Taylor & Francis in Hospital Practice
- Vol. 9 (6), 99-107
- https://doi.org/10.1080/21548331.1974.11708029
Abstract
The concept that the cyclic nucleotides are the bridge between a hormonal stimulus and the interior apparatus of the target cell seems to describe an “open loop” system lacking a feedback control to turn off the nucleotide once the cell has responded appropriately. But an interrelated nucleotide-cation system fills this conceptual gap, clarifying the role of the ions, especially Ca++, in mediating hormonal action.Keywords
This publication has 4 references indexed in Scilit:
- Insulin secretion: Multifactorial regulation for a single process of releaseDiabetologia, 1973
- Role of Calcium and Adenosine-3′:5′-Cyclic Monophosphate in Controlling Fly Salivary Gland SecretionProceedings of the National Academy of Sciences, 1972
- The Role of Cyclic AMP and Calcium in Cell ActivatioCRC Critical Reviews in Biochemistry, 1972
- Cell Communication, Calcium Ion, and Cyclic Adenosine MonophosphateScience, 1970