Enzymatic Synthesis of a Ring-Contracted Analogue of 5-Enolpyruvylshikimate-3-phosphate
- 1 October 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (22), 4065-4067
- https://doi.org/10.1021/ol048260z
Abstract
Three ring-contracted mimics of shikimate-3-phosphate, formed from the triols by shikimate kinase, were evaluated as substrates of the next enzyme in the pathway, EPSP synthase. The cyclopentylidene analogue (+)-2P was converted enzymatically to the enolpyruvyl derivative, thus demonstrating the second step of an artificial biosynthetic sequence.Keywords
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