Detoxification of Cottonseed Pigment Glands with Ferrous Sulfate

Abstract

Acute toxicity studies were made on 3 different samples of cottonseed pigment glands admd. orally to 228 rats in the form of slurries made with either dist. water or 2% ferrous sulfate soln. The LD50 values for the samples when administered in water were, respectively, 1140, 1490 and 2290 mg./kg. When suspended in 2% ferrous sulfate soln. the samples were detoxified so that even such high doses as 7000 mg./kg. for each were no longer toxic. There was little effect on the body wt. of all 99 rats which survived doses of ferrous sulfate-treated cottonseed pigment glands 3 to 6 times the LD50 values for water-suspended glands. Admn. of pigment glands in 0.5% FeSO4 did not detoxify them and led to the death of all 24 rats given this prepn.