Genetic control of DNA specificity inPseudomonas aeruginosa

Abstract
Genotypic and phenotypic changes of HCM in P. aeruginosa are due to a variety of causes. In addition to interstrain genetic differences and the semi-permanent effects of growth at 43°C, mutations affecting both restriction and modification have been isolated by direct selection and through the pleiotropic effects of p–fluorophenylalanine resistance mutations. It is suggested that some of these changes affecting HCM may be taking place through alterations of the ribosomes.