The authors collected a series of 10 cases of the adrenocortical syndrome in [female][female], 6 caused by carcinoma of the adrenal cortex, 2 caused by adenoma of the adrenal cortex, 1 case with a massive intraadrenal hemorrhage, and 1 case caused apparently by a lesion of the pituitary gland. Clinically, these patients showed mas-culinization, the severity depending on the extent of the lesion and the age of the patient. The treatment consisted of unilateral adrenalectomy or partial adrenal resection, depending on the lesion. The prognosis is fair, considering that the opposite adrenal is often atrophic.