Regulation of Amino Acid Transport in Kidney Cortex of Newborn Rats

Abstract

After incubation at 37°C the subsequent uptake of α-aminoisobutyric acid, cycloleucine, glycine, and L-proline by newborn (as compared to adult) rat kidney cortex slices is enhanced. The effect is abolished by the presence of cycloheximide, actinomycin D, and high concentrations of the above-mentioned amino acids in the medium during the 37°C incubation prior to measurement of uptake. The data suggest that there is an adaptive control mechanism which is expressed on incubation at 37°C and which can regulate amino acid transport in newborn rat kidney cortex.