Global Challenge of Antibiotic-Resistant Treponema pallidum
- 1 February 2010
- journal article
- review article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 54 (2), 583-589
- https://doi.org/10.1128/aac.01095-09
Abstract
Syphilis is a multistage infectious disease that is usually transmitted through contact with active lesions of a sexual partner or from an infected pregnant woman to her fetus. Despite elimination efforts, syphilis remains endemic in many developing countries and has reemerged in several developed countries, including China, where a widespread epidemic recently occurred. In the absence of a vaccine, syphilis control is largely dependent upon identification of infected individuals and treatment of these individuals and their contacts with antibiotics. Although penicillin is still effective, clinically significant resistance to macrolides, a second-line alternative to penicillin, has emerged. Macrolide-resistant strains of Treponema pallidum are now prevalent in several developed countries. An understanding of the genetic basis of T. pallidum antibiotic resistance is essential to enable molecular surveillance. This review discusses the genetic basis of T. pallidum macrolide resistance and the potential of this spirochete to develop additional antibiotic resistance that could seriously compromise syphilis treatment and control.Keywords
This publication has 94 references indexed in Scilit:
- Macrolide Resistance and Molecular Types ofTreponema pallidumCausing Primary Syphilis in Shanghai, ChinaClinical Infectious Diseases, 2009
- Molecular Characterization of Syphilis in Patients in Canada: Azithromycin Resistance and Detection of Treponema pallidum DNA in Whole-Blood Samples versus Ulcerative SwabsJournal of Clinical Microbiology, 2009
- Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidumJournal of Medical Microbiology, 2009
- Complete genome sequence of Treponema pallidum ssp. pallidumstrain SS14 determined with oligonucleotide arraysBMC Microbiology, 2008
- Detection of Azithromycin Resistance in Treponema pallidum by Real-Time PCRAntimicrobial Agents and Chemotherapy, 2007
- Detection of Treponema pallidum subsp. pallidum from Skin Lesions, Serum, and Cerebrospinal Fluid in an Infant with Congenital Syphilis after Clindamycin Treatment of the Mother during PregnancyJournal of Clinical Microbiology, 2007
- Natural Rifampin Resistance in Treponema spp. Correlates with Presence of N531 in RpoB Rif Cluster I Antimicrobial Agents and Chemotherapy, 2001
- A Pilot Study Evaluating Ceftriaxone and Penicillin G as Treatment Agents for Neurosyphilis in Human Immunodeficiency Virus-Infected IndividualsClinical Infectious Diseases, 2000
- Molecular cloning and characterization of Borrelia burgdorferi rpoBGene, 1997
- Ceftriaxone Therapy for Incubating and Early SyphilisThe Journal of Infectious Diseases, 1988