Effect of growth hormone of free fatty acid metabolism
- 1 January 1964
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 206 (1), 174-178
- https://doi.org/10.1152/ajplegacy.1964.206.1.174
Abstract
Bovine growth hormone (GH) was administered at 1 mg/kg day for various periods of time to normal dogs. The effects produced on plasma free fatty acid (FFA) metabolism were studied in these animals, in the unanesthetized state, using palmitate-C14. At 3–9 hr following intravenous injection of growth hormone significant increase were observed in plasma FFA concentration, turnover rate, total amount of FFA oxidized to CO2, and per cent of total respiratory CO2 derived from FFA. FFA production was increased by GH; FFA uptake and oxidation increased in parallel with plasma FFA concentration and apparently were not affected directly by GH. Similar changes were observed after 2 days of GH. After 7 days of GH all these parameters returned to control values. The transient effect of GH on FFA metabolism is in contrast with its reported prolonged effects on fat metabolism; possible reasons for this discrepancy are discussed.Keywords
This publication has 17 references indexed in Scilit:
- Measurement of Size and Turnover Rate of Body Glucose Pool by the Isotope Dilution MethodAmerican Journal of Physiology-Legacy Content, 1956
- Carbohydrate Metabolism of Hypophysectomized Dogs as Studied With Radioactive GlucoseAmerican Journal of Physiology-Legacy Content, 1956
- UNESTERIFIED FATTY ACID IN HUMAN BLOOD PLASMA 1JCI Insight, 1956
- A RELATION BETWEEN NON-ESTERIFIED FATTY ACIDS IN PLASMA AND THE METABOLISM OF GLUCOSEJCI Insight, 1956
- THE EFFECT OF GROWTH HORMONE ON LIPOGENESIS IN INTACT AND ADRENALECTOMIZED RATSEndocrinology, 1955
- SITE OF FORMATION OF PLASMA PHOSPHOLIPIDES STUDIED WITH C14-LABELED PALMITIC ACIDJournal of Biological Chemistry, 1950
- A study of the source of liver fat using deuterium as an indicatorThe Journal of Physiology, 1938
- Anterior pituitary extracts and liver fat1The Journal of Physiology, 1936
- Anterior Pituitary Growth Hormone and the Composition of GrowthJournal of Nutrition, 1934
- SOME EFFECTS OF ANTERIOR PITUITARY EXTRACTS ON NITROGEN METABOLISM, WATER BALANCE, AND ENERGY METABOLISMThe Journal of Experimental Medicine, 1933