INHIBITION OF HUMAN-MELANOMA COLONY FORMATION BY RETINOIDS
- 1 January 1979
- journal article
- research article
- Vol. 39 (10), 4055-4057
Abstract
The effects of retinoids [retinal, .beta.-all-trans-retinoic acid and 13-cis-retinol] were studied on the in vitro survival of melanoma colony-forming cells in biopsies obtained from 10 patients with metastatic melanoma. Specific retinoids apparently reduce the ability of fresh human melanoma cells to form colonies in soft agar. The retinoids studied had differential effects on the survival of clonogenic melanoma cells, and these effects vary from patient to patient. The data provide support for the clinical trial of selected retinoids in micrometastatic and advanced melanoma.This publication has 13 references indexed in Scilit:
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