Urinary excretion of histamine and some of its metabolites in man: Influence of the diet
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (3-4), 189-194
- https://doi.org/10.1007/bf01972348
Abstract
Urinary excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined in 10 normal subjects on 3 different diets, containing a very low protein, a low protein and a high protein amount. Foodstuffs which could contain histamine were excluded. The mean excretion ofN τ-methylhistamine on the second day of each diet amounted to 0.861 μmol/24 h, 1.051 μmol/24 h and 1.378 μmol/24 h, respectively. The excretions of histamine andN τ-methylimidazoleacetic acid were not affected. In 6 normal persons on a protein low diet, the excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined for 10 days. On the fifth day, to 3 persons 200 μmol of histamine was given orally, the other 3 persons received a high protein diet. The persons receiving histamine showed a strongly enhanced excretion ofN τ-methylimidazoleacetic acid, corresponding to 36.1% of the administered histamine, whereas the urinary excretions of histamine andN τ-methylhistamine were only slightly elevated. On the high protein diet, only the excretion ofN τ-methylhistamine was slightly elevated. The urinary excretions of histamine in the female subjects sometimes showed unexpectedly high values. Most probably, this phenomenon is attributable to bacterial histamine production in the urogenital tract.This publication has 22 references indexed in Scilit:
- Determination of histamine by chemical ionization mass spectrometry: Application to human urineJournal of Mass Spectrometry, 1983
- Measurement of plasma histamine in asthmaClinical and Experimental Allergy, 1983
- Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasmaInflammation Research, 1982
- The demonstration of histamine release in clinical conditions: A review of past and present assay proceduresKlinische Wochenschrift, 1982
- Concentration effect relationships of infused histamine in normal volunteersInflammation Research, 1982
- Influence of dietary histidine on tissue histamine concentration, histidine decarboxylase and histamine methyltransferase activity in the ratInflammation Research, 1981
- Histamine levels in plasma, blood, and urine in severe asthma, and the effect of corticosteroid treatment.Thorax, 1976
- Naming of substituted histaminesCellular and Molecular Life Sciences, 1974
- Urinary Excretion of Histamine, Methylhistamine and Methylimidazoleacetic Acids in Man under Standardized Dietary ConditionsScandinavian Journal of Clinical and Laboratory Investigation, 1968
- Effects of Oral Histamine, Histidine and Diet on Urinary Excretion of Histamine, Methylhistamine and 1-Methyl-4-imidazoleacetic Acid in ManScandinavian Journal of Clinical and Laboratory Investigation, 1968