Potentiation of Invasive Capacity of Rat Ascites Hepatoma Cells by Transforming Growth Factor‐β
- 1 February 1989
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 80 (2), 107-110
- https://doi.org/10.1111/j.1349-7006.1989.tb02275.x
Abstract
The in vitro invasive capacity of poorly invasive cells (W1), which were cloned from rat ascites hepatoma cells (AH 130), was potentiated dose- and time-dependently by pretreating the cells with transforming growth factor-.beta. (TGF-.beta.). This potentiation of invasive capacity was completely abolished by anti-TGF-.beta. antibody. When the treated cells were ip inoculated into rats, the cells extensively invaded the peritoneum, and formed penetrating tumor nodules. The effect of TGF-.beta. was reversed by subculturing the treated cells without TGF-.beta.. The potentiation of invasive capacity by TGF-.beta. might participate in platelet-associated enhancement of tumor cell metastasis.Keywords
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