Pharmacokinetics of canrenone after oral administration of spironolactone and intravenous injection of canrenoate-K in healthy man
- 1 January 1983
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 25 (4), 449-453
- https://doi.org/10.1007/bf00542109
Abstract
Five healthy male volunteers received canrenoate-K 200 mg (Sincomen® pro injectione) by intravenous injection and one week later spironolactone 200 mg (Sincomen®-100) orally. Plasma levels and urinary excretion of unchanged canrenone were determined up to 24 h by a specific HPLC method. Following intravenous administration, the maximum plasma level of 2066±876 ng/ml was found after 29±15 min and thereafter the concentration declined with a half-life of 3.7±1.2 h. Total clearance was 4.2±1.7 ml/min·kg. After oral ingestion, the maximum concentration of 177±33 ng/ml was observed at 4.4±0.9 h. The absolute bioavailability of canrenone was 25±9%. Within 24 h, respectively 0.4 and 0.6 mg, canrenone were excreted by the kidney after intravenous and oral administration. The half-life of elimination was 4.9±1.8 h (i.v.) and 3.9±1.2 h (p.o.).This publication has 9 references indexed in Scilit:
- RE-EVALUATION OF THE ANTI-MINERALOCORTICOID EFFECT OF THE SPIRONOLACTONE METABOLITE, CANRENONE, FROM PLASMA-CONCENTRATIONS DETERMINED BY A NEW HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC METHOD1979
- Kinetics of canrenone after single and multiple doses of spironolactoneEuropean Journal of Clinical Pharmacology, 1979
- Spironolactone and canrenoate‐K: Relative potency at steady stateClinical Pharmacology & Therapeutics, 1977
- Antagonism of fludrocortisone by spironolactone and canrenone [letter].British Journal of Clinical Pharmacology, 1976
- Spironolactone. I. Disposition and metabolismClinical Pharmacology & Therapeutics, 1976
- Pharmacokinetics of spironolactone in manNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- Spironolactone metabolism in man studied by gas chromatography-mass spectrometry.1975
- Pharmacokinetics of spironolactone, canrenone and canrenoate-K in humans.1973
- Pharmacokinetic and Metabolic Fate of Potassium Canrenoate (SC-14266) in ManJournal of Pharmaceutical Sciences, 1971