THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION
Open Access
- 30 November 1963
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 21 (3), 581-589
- https://doi.org/10.1111/j.1476-5381.1963.tb02025.x
Abstract
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the poly-functional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.Keywords
This publication has 13 references indexed in Scilit:
- METABOLIC STUDIES WITH DI(AZIRIDIN‐I‐YL) SULPHOXIDE (DIETHYLENEIMINOSULPHOXIDE)British Journal of Pharmacology and Chemotherapy, 1963
- Whole Body X-Irradiation, Nitrogen Excretion and the Adrenal GlandEndocrinology, 1962
- Comparative Studies of the Diuretics Acetazolamide, Aminometradine, Chlorothiazide and TheophyllineActa Pharmacologica et Toxicologica, 1961
- Comparative effects of certain alkylating agents on the proliferation of normal and tumour tissue-haematopoiesis.1960
- THE EFFECT OF ALKYLATING AGENTS ON MALE RAT FERTILITYBritish Journal of Pharmacology and Chemotherapy, 1959
- PHARMACOLOGY OF SPERMINE AND SPERMIDINE - SOME EFFECTS ON ANIMALS AND BACTERIA1956
- Excretion Patterns of Rats Following Total-Body Exposure to X-radiationScience, 1955
- Experimental medullary necrosis of the kidney; a morphologic and functional study.1951
- Über einige Reaktionen des Äthylen‐iminsEuropean Journal of Organic Chemistry, 1950
- THE ACTION OF MERSALYL, CALOMEL AND THEOPHYLLINE SODIUM ACETATE ON THE KIDNEY OF THE RATBritish Journal of Pharmacology and Chemotherapy, 1946