Influence of DCA and Cortisone on Adrenal Glands of Fed and Acutely Starved Hamsters

Abstract

Compensatory adrenal atrophy is produced readily in fed hamsters by DCA (2-5 mg/day ), whereas cortisone acetate ( 5-10 mg/day ) does not affect adrenal weight significantly. The cytological changes observed in adrenals of fed animals after cortisone acetate administration are similar to those found in adrenals of acutely starved hamsters. Neither DCA nor cortisone acetate alter significantly the adrenal changes produced by acute starvation.