Unified theory of collapse, folding, and glass transitions in associative-memory Hamiltonian models of proteins
- 1 December 1992
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review A
- Vol. 46 (12), 7979-7997
- https://doi.org/10.1103/physreva.46.7979
Abstract
A unified variational theory is developed for collapse, folding, and glass transitions of the proteins modeled by associative-memory Hamiltonians. The mechanisms and conditions of transitions are studied, and the phase diagram is discussed. A quantitative measure of feasibility of folding and an upper bound of memory capacity are derived. The variational method gives several insights to improve simulations for protein-structure predictions.Keywords
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