The Testicular Feminized Rat: A Naturally Occurring Model of Androgen Independent Brain Masculinization
- 18 July 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4454), 418-420
- https://doi.org/10.1126/science.7384816
Abstract
Although genotypically male (XY), the testicular feminized rat develops as an anatomic female because of an inherited deficiency in intracellular androgen receptors that prevents androgen imprinting of sexual primordia. However, the ability of testicular feminized rats to exhibit male-like sexual behavior and little feminine sexual behavior suggests that the brain can be masculinized without androgens.Keywords
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