DIFFERENCES IN MATURATION OF IMMUNE-RESPONSE OF A-RABBITS AND A+RABBITS - GOOD AND POOR RESPONDERS RESPECTIVELY FOR A-ANTIGEN
- 1 January 1977
- journal article
- research article
- Vol. 33 (1), 91-100
Abstract
The amount, avidity and specificity of anti-A antibodies produced by rabbits having the A substance in their secretions (A+) and rabbits lacking this antigen (A-) were studied with a series of antigens chemically related to the A substance. A- and A+ rabbits produced specific anti-A antibodies, but the amount, maturation of avidity and specificity of these antibodies was completely different. The difference between the immune response of A+ and A- animals may not be based on a genetically determined inability of A+ rabbits to recognize the self antigen, but rather on differences in the regulatory mechanism(s) controlling the maturation process of the anti-A response.This publication has 25 references indexed in Scilit:
- Determination of the structure of the immunodominant groups of the canine secretory alloantigens (CSA) by radioimmunoassay.1975
- Purification, 125I labeling, and immunochemical study of the canine secretory alloantigens (CSA).1975
- The genetic control of antibody affinity in mice.1975
- A Disquisition on Suppressor T CellsImmunological Reviews, 1975
- Characterization by mass spectrometry of blood group A active glycolipids from human and dog small intestineBiochemistry, 1975
- Structure of forssman hapten glycosphingolipid from sheep erythrocytesImmunochemistry, 1974
- Studies of digestive groups. I. The A alloantigen-alloantibody system in rabbits.1973
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964
- The Influence of the A-Like Substance of Rabbits on Their Immune Response to Human Blood-Group A-SubstanceThe Journal of Immunology, 1956
- INFLUENZA: THE NEWE ACQUAYANTANCEAnnals of Internal Medicine, 1953