A diet enriched in vitamin A acetate orin vivoadministration of interleukin-2 can counteract a tolerogenic stimulus

Abstract

A conventional diet enriched in retinyl acetate (vitamin A acetate; VAA) or in vivo administration of exogenous interleukin-2 (IL-2) can effectively annul the otherwise tolerogenic stimulus represented by (CBA $\times $ C57BL/10ScSn) F$_{1}$ cells injected intraperitoneally into newborn CBA mice. On the basis of these data and results of others, we postulate that an antigenic stimulus associated with a relative lack of IL-2 (or generally the lack of a `secondary stimulus') can be tolerogenic rather than immunogenic. However, the tolerogenicity of the antigenic stimulus can be substantially reduced or even converted to sensitization (R. P. Cleveland & H. N. Claman, J. Immun. 124, 474-480, 1980), when the antigenic signal is appropriately associated with a concomitant or additional stimulus possibly mediated through IL-2.