LNHIBITION OF BOWEL EPITHELIUM REGENERATION BY GRAFTED HOMOLOGOUS SPLEEN CELLS IN IRRADIATED MICE

Abstract

LAF1 mice exposed to an X-ray dose of 870-900 r and injected intraperitoneally with homologous or parental strain spleen cells died 4-8 days after irradiation, with pathological changes typical of the intestinal syndrome. It is suggested that these accelerated deaths result from a specific homograft reaction of the implanted cells against the bowel epithelium of the host.