A NEW PROCEDURE FOR SCREENING ANTITUBERCULOUS AGENTS - EFFECT OF CHEMOTHERAPEUTIC AGENTS ON MICE INFECTED WITH MASSIVE DOSES OF TUBERCLE BACILLI INTRAPERITONEALLY

Abstract

The method consists of injecting intraperit. massive doses of human tubercle bacilli into mice. Chemotherapy is begun after 48 hrs. and continued for 7 days. Food consumption, body wt., and mortality of the mice were followed for 3 wks. At the end of this period, autopsy is performed on the remaining mice and macroscopic lesions counted.