The Ototoxicity of Kanamycin Sulfate in the Presence of Compromised Renal Function

Abstract

The potential ototoxicity of some antibiotics is well recognized, the most notable examples being streptomycin,¹ dihydrostreptomycin, and neomycin. Our recent experience with two cases, who suffered eighth nerve damage following the administration of kanamycin sulfate (Kantrex²), is presented as a reminder of the risks involved and as an illustration that these risks may be much increased in the presence of compromised renal function. Case 1.—A 40-year-old white male paraplegic, a veteran of World War II. His general health had been excellent until a shrapnel injury in 1945 resulted in total paraplegia. He was successfully rehabilitated after four years of hospitalization and has been able to drive his own car and operate a successful accounting business. A cordotomy was performed in 1956 because of increasingly severe burning pain in the lower extremities. After six weeks the pain recurred, and the patient has since become addicted to dihydromorphinone (Dilaudid). From